Soluble Aβ42 is detectable by 1.5 months and its levels increase steeply with age. Females express somewhat more APP than males, probably due to an estrogen response element in the Thy1 promoter used to drive transgene expression ( Sadleir et al., 2015 Sadleir et al., 2018), and generate higher levels of Aβ ( Oakley et al., 2006 Maarouf et al., 2013). Levels of human APP in whole brain have been reported as between half ( Sadleir et al., 2018) and three times ( Ohno et al., 2006) that of endogenous mouse APP, and levels of transgenic PS1 as half those of the endogenous protein ( Sadleir et al., 2018). The descriptions on this page refer to mice hemizygous for the APP and PSEN1 transgenes. Mice display a range of cognitive and motor deficits. Neuron loss occurs in multiple brain regions, beginning at about 6 months in the areas with the most pronounced amyloidosis. Amyloid pathology is more severe in females than in males. Amyloid plaques, accompanied by gliosis, are seen in mice as young as two months of age. These widely used mice recapitulate many AD-related phenotypes and have a relatively early and aggressive presentation. Tg6799 mice are also available on a congenic C57BL6 background, described elsewhere. The Tg6799 line, which expresses the highest levels of mutant APP, is the most studied of the three, and is described here on the original hybrid B6SJL background. Three lines were generated originally: Tg6799, Tg7031, and Tg7092. SummaryĥxFAD mice express human APP and PSEN1 transgenes with a total of five AD-linked mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP, and the M146L and L286V mutations in PSEN1. Research with this model is available from QPS Austria. Innovative art style combines retro future design with modern technologyīecome fully immersed: shoot, brawl, crawl, climb, leap and think your way through Citadel Station.Species: Mouse Genes: APP, PSEN1 Mutations: APP K670_M671delinsNL (Swedish), APP I716V (Florida), APP V717I (London), PSEN1 M146L (A>C), PSEN1 L286V Modification: APP: Transgenic PSEN1: Transgenic Disease Relevance: Alzheimer's Disease Strain Name: B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax Genetic Background: C57BL/6 x SJL Availability: The Jackson Lab available through the JAX MMRRC Stock# 034840 Live. Jack into cyberspace to hack the system and open other routes Discover a non-linear story unfolding at your own pace Improve your skills and adapt to take on your foes Face off against the forces of a rogue AI gone mad Stop SHODAN and avert humanity’s destruction. ![]() You must explore and battle your way through the depths of a space station gone to hell. The psychotic AI has taken control of Citadel Station and turned the crew into an army of cyborgs and mutants She now plans to do the same to Earth. Witness the rebirth of one of the greatest and most influential games ever created. System Shock is the fully fledged remake of the ground breaking original from 1994, combining cult gameplay with all-new HD visuals, updated controls, an overhauled interface and all-new sounds & music it even has the original voice actor of SHODAN, one of gaming’s most iconic villains.
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